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<center><span style="color: | <center> [[Software#Toolboxes for research|<span style="color:GreenYellow;">More on Snapdragon model</span>]] </center> | ||
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=<span style="color: Gold">Genes and growing shapes<span>= | =<span style="color: Gold">Genes and growing shapes<span>= | ||
<span style="color: LemonChiffon">The aim is to understand how patterns of gene activity in biological organs influence the developing shape. A key notion is that genes may regulate direction independently of growth rate. We formalised our ideas in the Growing Polarised Tissue Framework (ref). To make it easy to develop ideas on the relationship between growth and form we implemented a software package: ''GFtbox''. Using ''GFtbox'' one can start with a simple sheet of tissue (the canvas), lay out experimentally observed, or hypothesised, patterns of regulator activity and then grow the canvas in 3D. The final shape can be compared quantitatively with it's biological counterpart.</span><p> | <span style="color: LemonChiffon">The aim is to understand how patterns of gene activity in biological organs influence the developing shape. A key notion is that genes may regulate growth direction independently of growth rate. We formalised our ideas in the Growing Polarised Tissue Framework (ref). To make it easy to develop ideas on the relationship between growth and form we implemented a software package: ''GFtbox''. Using ''GFtbox'' one can start with a simple sheet of tissue (the canvas), lay out experimentally observed, or hypothesised, patterns of regulator activity and then grow the canvas in 3D. The final shape can be compared quantitatively with it's biological counterpart - so testing the hypotheses.</span><p> | ||
<center><span style="color: | <center> [[Software#Toolboxes for research|<span style="color:GreenYellow;">Downloads and more details on ''GFtbox''</span>]] </center> | ||
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<center> [[Software#Toolboxes for research|<span style="color:GreenYellow;">More | <center> [[Software#Toolboxes for research|<span style="color:GreenYellow;">More on testing models</span>]] </center> | ||
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Revision as of 17:29, 3 May 2011
The Bangham Lab
The Bangham Lab is part of the UEA D’Arcy Thompson Centre for computational biology.
Computational Biology
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<sgallery width="160" height="280" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="2000"> LabelledCropped_GPT_Snapdragon_2010-000250-0001.png LabelledCropped_GPT_Snapdragon_2010-000340-0001.png LabelledCropped_GPT_Snapdragon_2010-000490-0001.png LabelledCropped_GPT_Snapdragon_2010-000570-0002.png LabelledCropped_GPT_Snapdragon_2010-000570-0003.png LabelledCropped_GPT_Snapdragon_2010-000570-0004.png LabelledCropped_GPT_Snapdragon_2010-000570-0005.png LabelledCropped_GPT_Snapdragon_2010-000570-0007.png LabelledCropped_GPT_Snapdragon_2010-000570-0006.png LabelledCropped_GPT_Snapdragon_2010-000570-0001.png </sgallery> |
Genes and growing shapesThe aim is to understand how patterns of gene activity in biological organs influence the developing shape. A key notion is that genes may regulate growth direction independently of growth rate. We formalised our ideas in the Growing Polarised Tissue Framework (ref). To make it easy to develop ideas on the relationship between growth and form we implemented a software package: GFtbox. Using GFtbox one can start with a simple sheet of tissue (the canvas), lay out experimentally observed, or hypothesised, patterns of regulator activity and then grow the canvas in 3D. The final shape can be compared quantitatively with it's biological counterpart - so testing the hypotheses.
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<sgallery width="160" height="280" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="4000"> LabelledCropped GPT Snapdragon 2010-000570-0003 double.png LabelledCropped GPT Snapdragon 2010-000570-0002 triple.png LabelledCropped GPT Snapdragon 2010-000570-0001-Wildtype.png </sgallery> |