Main Page: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
=<span style="color: DarkGreen">Computational Biology= | =<span style="color: DarkGreen">Computational Biology= | ||
<span style="color: DarkGreen"><font size="+1">The aim </font><span>is to understand how patterns of gene activity in biological organs influence the developing shape. </span><p></p><p></p> | <span style="color: DarkGreen"><font size="+1">The aim </font><span>is to understand how patterns of gene activity in biological organs influence the developing shape. </span><p></p><p></p> | ||
{| border=" | {| border="0" cellpadding="5" cellspacing="3" style="background-color: #000000;" | ||
| <!-- column1--> | | <!-- column1--> | ||
<sgallery width=" | <sgallery width="140" height="200" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="2000"> | ||
LabelledCropped_GPT_Snapdragon_2010-000250-0001.png | LabelledCropped_GPT_Snapdragon_2010-000250-0001.png | ||
LabelledCropped_GPT_Snapdragon_2010-000340-0001.png | LabelledCropped_GPT_Snapdragon_2010-000340-0001.png | ||
| Line 24: | Line 24: | ||
* <span style="color: LemonChiffon">Formalised in the Growing Polarised Tissue Framework (ref). </span> | * <span style="color: LemonChiffon">Formalised in the Growing Polarised Tissue Framework (ref). </span> | ||
* <span style="color: LemonChiffon">Implemented in ''GFtbox'' to make it easy to develop ideas on growth and form.</span> | * <span style="color: LemonChiffon">Implemented in ''GFtbox'' to make it easy to develop ideas on growth and form.</span> | ||
* <span style="color: LemonChiffon">Start with a sheet of tissue (the canvas) | * <span style="color: LemonChiffon">Start with a sheet of tissue (the canvas) with observed, or hypothetical patterns of growth factor activity. </span> | ||
* <span style="color: LemonChiffon">Grow the canvas in 3D | * <span style="color: LemonChiffon">Grow the canvas in 3D under constraints of tissue continuity</span> | ||
* <span style="color: LemonChiffon">Compare with observed data quantitatively </span><p> | * <span style="color: LemonChiffon">Compare with observed data quantitatively </span><p> | ||
<center> [[Software#Toolboxes for research|<span style="color:GreenYellow;">Downloads and more details on ''GFtbox''</span>]] </center> | <center> [[Software#Toolboxes for research|<span style="color:GreenYellow;">Downloads and more details on ''GFtbox''</span>]] </center> | ||
|| <!-- column3--> | || <!-- column3--> | ||
<sgallery width=" | <sgallery width="140" height="200" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="3000"> | ||
LabelledCropped GPT Snapdragon 2010-000570-0003 double.png | LabelledCropped GPT Snapdragon 2010-000570-0003 double.png | ||
LabelledCropped GPT Snapdragon 2010-000570-0002 triple.png | LabelledCropped GPT Snapdragon 2010-000570-0002 triple.png | ||
Revision as of 10:30, 4 May 2011
Computational Biology
The aim is to understand how patterns of gene activity in biological organs influence the developing shape.|
<sgallery width="140" height="200" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="2000"> LabelledCropped_GPT_Snapdragon_2010-000250-0001.png LabelledCropped_GPT_Snapdragon_2010-000340-0001.png LabelledCropped_GPT_Snapdragon_2010-000490-0001.png LabelledCropped_GPT_Snapdragon_2010-000570-0002.png LabelledCropped_GPT_Snapdragon_2010-000570-0003.png LabelledCropped_GPT_Snapdragon_2010-000570-0004.png LabelledCropped_GPT_Snapdragon_2010-000570-0005.png LabelledCropped_GPT_Snapdragon_2010-000570-0007.png LabelledCropped_GPT_Snapdragon_2010-000570-0006.png LabelledCropped_GPT_Snapdragon_2010-000570-0001.png </sgallery> |
Genes and growing shapes
|
<sgallery width="140" height="200" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="3000"> LabelledCropped GPT Snapdragon 2010-000570-0003 double.png LabelledCropped GPT Snapdragon 2010-000570-0002 triple.png LabelledCropped GPT Snapdragon 2010-000570-0001-Wildtype.png </sgallery> |
|
<sgallery width="160" height="280" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="1500"> Arabidopsis_Leaf_ATH8bbg.png Antirrhinum flower small1.jpg Antirrhinum flower small2.jpg Antirrhinum flower small3.jpg Anthers1.jpg MacroOPTIris1.jpg </sgallery> |
Working with 3D volume imagesThree dimensional (3D) volume images are key to understanding the development of shape. They are produced by CT X-ray scanners, MRI and PET. However, biological gene activity is monitored using fluorescent probes and so optical methods are used: confocal microscopy and optical projection microscopy. The resulting images are large and are best viewed using software that exploits powerful graphics processors. We implemented VolViewer which is a viewer of choice in the open microscopy environment. |
<sgallery width="160" height="280" showarrows="false" showcarousel="false" showinfopane="false" timed="true" delay="4000"> Arabidopsis_Leaf_ATH8bbg.png </sgallery> |
Photos, Algorithms and Art
Tools and Demonstrations
About
The Bangham Lab is part of the UEA D’Arcy Thompson Centre for computational biology.