GFtbox Workshop pages

Workshop on GFtbox

Exercise

The aim is to practice modelling growth using as many features of the GFtbox as sensible. The challenge is to model the early development of the mouse heart from a simple tube to stage E9.5. By this stage the tube has grown, twisted through 90 degrees, bent and started to balloon and form the atrial and ventricular surfaces. The deformations might arise from an evolving pattern of isotropic specified growth or might arise from anisotropic specified growth. It is not known.

In the wind-up session, groups will be invited to describe their successes and failures and there will be votes for the best, the wackiest and the worst models.


Stage ED9.5 having started growth as a simple tube. Click here for web page
Model the developing mouse heart.

Links

Interactive 3D model of the mouse heart
Illustrations of the developing mouse heart
'Three-dimensional reconstruction of gene expression patterns during cardiac development' by Alexandre T. Soufan , Jan M. Ruijter , Maurice J. B. van den Hoff , Piet A. J. de Boer , Jaco Hagoort and Antoon F. M. Moorman
[http://jcb.rupress.org/content/164/1/97.full.pdf 'Oriented clonal cell growth in the developing mouse myocardium underlies cardiac morphogenesis' by Sigolène M. Meilhac, Milan Esner, Michel Kerszberg, Julie E. Moss, and Margaret E. Buckingham]
Cardiac laterality: The role of the homeobox transcription factor Pitx2 in cardiogenesis