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The Bangham Lab
The Bangham Lab is part of the UEA D’Arcy Thompson Centre for computational biology.
Computational Biology
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Genes and growing shapesThe aim is to understand how patterns of gene activity in biological organs influence the developing shape. A key notion is that genes may regulate growth direction independently of growth rate. We formalised our ideas in the Growing Polarised Tissue Framework (ref). To make it easy to develop ideas on the relationship between growth and form we implemented a software package: GFtbox. Using GFtbox one can start with a simple sheet of tissue (the canvas), lay out experimentally observed, or hypothesised, patterns of regulator activity and then grow the canvas in 3D. The final shape can be compared quantitatively with it's biological counterpart - so testing the hypotheses.
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